An efficient synthesis of spirocyclopropane derivatives was achieved via [2+1] annulation of α,β-carbonyl compounds with nitroacetates. The reactions had the advantages of simple operation, good functional group tolerance and excellent configurational selectivity.

Abstract

An efficient synthesis of spirocyclopropanes was developed via [2+1] annulation of α,β-unsaturated carbonyl compounds with nitroacetates. This protocol features advantages such as simple operation, broad substrate scope, high diastereoselectivity and good to excellent yields. Moreover, this work represents the first example of assembling spirocyclopropane derivatives from nitroacetates.