Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives

Publication date: 5 December 2023

Source: European Journal of Medicinal Chemistry, Volume 261

Author(s): Emiliano Rosatelli, Andrea Carotti, Bruno Cerra, Francesca De Franco, Daniela Passeri, Roberto Pellicciari, Antimo Gioiello

Synthesis of novel rhodamine type Anthrone Spiro-lactam (ASL) analogues and evaluation of antiviral activity against dengue and chikungunya viruses

Publication date: 5 December 2023

Source: European Journal of Medicinal Chemistry, Volume 261

Author(s): Ratanamala S. Darole, Pooja K. Bagad, Rajesh G. Gonnade, Kalichamy Alagarasu, Madhura Punekar, Shridhar Shukla, Deepti Parashar, Beeran Senthilkumar

Development of chalcone-like derivatives and their biological and mechanistic investigations as novel influenza nuclear export inhibitors

Publication date: 5 December 2023

Source: European Journal of Medicinal Chemistry, Volume 261

Author(s): Chuanfeng Liu, Ying Zhang, Ping Li, Huinan Jia, Han Ju, Jiwei Zhang, Edeildo Ferreira da Silva-Júnior, Sunanda Samanta, Parimal Kar, Bing Huang, Xinyong Liu, Peng Zhan

Investigation of novel 5ʹ-amino adenosine derivatives with potential anti-Zika virus activity

Publication date: 5 December 2023

Source: European Journal of Medicinal Chemistry, Volume 261

Author(s): Xingjuan Chen, Yunzheng Yan, Huijuan Song, Zhuang Wang, Apeng Wang, Jingjing Yang, Rui Zhou, Shijie Xu, Shaokang Yang, Wei Li, Xiaoyu Qin, Qingsong Dai, Mingliang Liu, Kai Lv, Ruiyuan Cao, Wu Zhong

Design and synthesis of 1<em>H</em>-benzo[<em>d</em>]imidazole selective HDAC6 inhibitors with potential therapy for multiple myeloma

Publication date: 5 December 2023

Source: European Journal of Medicinal Chemistry, Volume 261

Author(s): Linfu Liu, Liyuan Zhang, Xuxi Chen, Kang Yang, Hao Cui, Rui Qian, Shanshan Zhao, Liqun Wang, Xiaolan Su, Manyu Zhao, Mengzhu Wang, Zan Hu, Tao Lu, Yong Zhu, Qing-Qing Zhou, Yuqin Yao

Design, synthesis, and biological evaluation of quinoline-piperazine/pyrrolidine derivatives as possible antileishmanial agents

Publication date: 5 December 2023

Source: European Journal of Medicinal Chemistry, Volume 261

Author(s): Sarita Katiyar, Karthik Ramalingam, Abhishek Kumar, Alisha Ansari, Amol Chhatrapati Bisen, Garvita Mishra, Sachin Nashik Sanap, Rabi Sankar Bhatta, Bidyut Purkait, Neena Goyal, Koneni V. Sashidhara