Category Archives: European Journal of Medicinal Chemistry

Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Tizhi Wu, Zhiming Zhang, Guangyue Gong, Zekun Du, Yifan Xu, Sixian Yu, Feihai Ma, Xuan Zhang, Yuxiao Wang, Haoming Chen, Shiqi Wu, Xi Xu, Zhixia Qiu, Zhiyu Li, Hongxi Wu, Jinlei Bian, Jubo Wang

Discovery of novel isopropanolamine inhibitors against <em>Mo</em>TPS1 as potential fungicides with unique mechanisms

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Zhiyang Jiang, Dongmei Shi, Yitong Chen, Huilin Li, Jin'e Wang, Xinrui Lv, Yunjiang Zi, Dongli Wang, Zhijian Xu, Jiaxing Huang, Junfeng Liu, Hongxia Duan

Synthesis of cannabidiol-based compounds as ACE2 inhibitors with potential application in the treatment of COVID-19

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Gabriel Vitor de Lima Marques, Daisymara Priscila de Almeida Marques, Felipe Alves Clarindo, Jesus Alberto Avendaño-Villarreal, Fabiana Sélos Guerra, Patrícia Dias Fernandes, Eduardo Nicolau dos Santos, Elena Vitalievna Gusevskaya, Markus Kohlhoff, Fabrício de Araújo Moreira, Luis Adan Flores Andrade, Flávio Guimarães da Fonseca, Jordana Grazziela Alves Coelho dos-Reis, Renata Barbosa de Oliveira

Synthesis and evaluation of 2-NMPA derivatives as potential agents for prevention of osteoporosis <em>in vitro</em> and <em>in vivo</em>

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Zhihao Chen, Devaneyan Joseph, Mina Ding, Swapnil Pandurang Bhujbal, Robin Prakash Sirvin Rajan, Eunae Kim, Sang-wook Park, Sunwoo Lee, Tae-Hoon Lee

Synthesis of 1,3,5-triphenyl-1,2,4-triazole derivatives and their neuroprotection by anti-oxidative stress and anti-inflammation and protecting BBB

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Yang Wang, Ruiqi Su, Jianwen Chen, Xuan Liu, Jingning Luo, Yaoqiang Lao, Ping Huang, Jinguo Shi, Caibao Jiang, Liping Liao, Jingxia Zhang

Design, synthesis and evaluation of novel pyrimidinylaminothiophene derivatives as FGFR1 inhibitors against human glioblastoma multiforme

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Yong-Liang Li, Long-Jia Yan, Hui-Xiong Chen, Ban-Kang Ruan, Pascal Dao, Zhi-Yun Du, Chang-Zhi Dong, Bernard Meunier