Integration of semi-empirical MS/MS library with characteristic features for the annotation of novel amino acid-conjugated bile acids

Analyst, 2023, Advance Article
DOI: 10.1039/D3AN01237A, Paper
Yan Ma, Yang Cao, Xiaocui Song, Weichen Xu, Zichen Luo, Jinjun Shan, Jingjie Zhou
Annotation of common and new amino acid-conjugated bile acids from LC-MS/MS data is achieved by an automatic workflow using a semi-empirical MS/MS library in negative ESI mode and characteristic fragments in positive ESI mode.
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An electronic tongue based on conjugated polymers for the discrimination and quantitative detection of tetracyclines

Analyst, 2023, 148,5152-5156
DOI: 10.1039/D3AN01213A, Paper
Shiyong Chen, Jie Wang, Zhikun Shang, Yun Ding, Aiguo Hu
A fluorescent sensor array has been developed based on conjugated polymers (CPs) having six different skeletons for the detection of tetracyclines (TCs), which are known as environmental pollutants.
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A feasible protocol to profile bile acids in dried blood spots from rats using a UHPLC-MS/MS method combining a surrogate matrix

Analyst, 2023, 148,5190-5202
DOI: 10.1039/D3AN00900A, Paper
Ziying Ma, Ning Sheng, Jinlan Zhang
A two-step method was applied to enable high extraction efficiency for bile acids in DBSs. A DBS surrogate matrix was well developed and showed good performance, and 35 bile acids were profiled using UHPLC-MS/MS with good resolution and quantified with acceptable precision and accuracy.
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Reporter emission multiplexing in digital PCRs (REM-dPCRs): direct quantification of multiple target sequences per detection channel by population specific reporters

Analyst, 2023, 148,5243-5254
DOI: 10.1039/D3AN00191A, Paper
Open Access Open Access
Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Silvia Calabrese, Anja M. Markl, Maximilian Neugebauer, Stefanie J. Krauth, Nadine Borst, Felix von Stetten, Michael Lehnert
Concept of reporter emission multiplexing (REM) to increase multiplexing capacities in digital PCR by using population specific reporters (PSR) labeled with fluorophores of different signal intensities.
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GC-FTICR mass spectrometry with dopant assisted atmospheric pressure photoionization: application to the characterization of plastic pyrolysis oil

Analyst, 2023, 148,5221-5232
DOI: 10.1039/D3AN01246H, Paper
Charlotte Mase, Julien F. Maillard, Marco Piparo, Lukas Friederici, Christopher P. Rüger, Sabrina Marceau, Benoit Paupy, Marie Hubert-Roux, Carlos Afonso, Pierre Giusti
GC-APPI-FTICR MS is particularly efficient for the characterization of complex organic mixtures such as plastic pyrolysis oil. The use of dopants allows control of ionization efficiency and selectivity to target specific families of molecules.
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High performance nonenzymatic electrochemical sensors via thermally grown Cu native oxides (CuNOx) towards sweat glucose monitoring

Analyst, 2023, Advance Article
DOI: 10.1039/D3AN01153D, Paper
Maksud M. Alam, Matiar M. R. Howlader
Diabetes, the seventh leading cause of death globally, requires real-time blood glucose monitoring, which is often an invasive process.
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Recent advances in aptamer-based biosensors for potassium detection

Analyst, 2023, Advance Article
DOI: 10.1039/D3AN01053H, Critical Review
Tengfang Zhang, Jiajia Liu, Linghao Zhang, Muhammad Irfan, Xin Su
This review focuses on aptasensors for K+ detection, their signal generation strategies, their analytical performance, factors that affect their efficiency with major challenges and future prospects.
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A reactive matrix for in situ chemical derivatisation and specific detection of cis-diol compounds by matrix-assisted laser desorption/ionisation mass spectrometry

Analyst, 2023, Advance Article
DOI: 10.1039/D3AN01400B, Paper
Jiajing Chen, Huan Huang, Dan Ouyang, Jiali Lin, Zhuling Chen, Zongwei Cai, Zian Lin
Based on the boronate affinity interaction between boric acid and cis-diols, 6-borono-1-methyl-quinoline-1-ium (BMQI) was designed and used as a reactive matrix for in situ derivatisation and rapid profiling of cis-diol compounds in MALDI-MS.
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Highly sensitive and rapid detection of hypochlorous acid in aqueous media and its bioimaging in live cells and zebrafish using an ESIPT-driven mycophenolic acid-based fluorescent probe

Analyst, 2023, 148,5203-5209
DOI: 10.1039/D3AN01340E, Paper
Prasad M. Sonawane, Neha Jain, Arkaprava Roychaudhury, Su Jeong Park, Vikas K. Bhosale, Mahesh B. Halle, Cheol-Hee Kim, Satish Balasaheb Nimse, David G. Churchill
Novel and photostable dimethylthiocarbamate (DMTC)-masked mycophenolic acid precursor is able to detect endogenous hypochlorite and doesn’t harm larval zebrafish's neuronal development.
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An improved algorithm for resolving overlapping peaks in ion mobility spectrometry and its application to the separation of glycan isomers

Analyst, 2023, Advance Article
DOI: 10.1039/D3AN01042B, Paper
Xiangyang Hu, Junfei Zhou, Junhui Li, Wenqing Gao, Jun Zhou, Jiancheng Yu, Keqi Tang
An improved algorithm for resolving overlapping peaks in ion mobility spectrometry was proposed and successfully applied to the separation of glycan isomers from both standard glycan overlapping peaks and real samples.
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