Establishing stereochemical comparability in phosphorothioate oligonucleotides with nuclease P1 digestion coupled with LCMS analysis

Analyst, 2023, Advance Article
DOI: 10.1039/D3AN01392H, Communication
Zifan Li, Fei Tong, Li Xiao, Nicholas R. Larson, Xuan Zhou, Yueheng Zhang, Jonas P. Immel-Brown, George M. Bou-Assaf
NP1 digestion coupled with UHPLC-HRMS can provide valuable information on stereochemical comparability between phosphorothioate oligonucleotides by examining digestion fragments.
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Developing an improved optical biosensing system based on gold nanoparticles acting as interferometric enhancers in Lactoferrin detection

Analyst, 2023, Advance Article
DOI: 10.1039/D3AN01328F, Paper
L. G. Valle, B. Santamaría, A. Lavín, M. F. Laguna, L. Rodriguez-Lorenzo, B. Espiña, M. Holgado
Antibody-coated goldnanoparticles (AuNPs) act as an interferometric enhancer, and their characterization, modeling, and comparison with ELISA.
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A layered cancer-on-a-chip system for anticancer drug screening and disease modeling

Analyst, 2023, Advance Article
DOI: 10.1039/D3AN00959A, Paper
Open Access Open Access
Magdalena Flont, Artur Dybko, Elżbieta Jastrzębska
Recent advances in the development of microfluidic systems for the culture of complex and three-dimensional cell, tissue, and organ models allow their use in toxicity studies and mimicking many diseases.
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Optical photothermal infrared spectroscopy and discrete wavenumber imaging for high content screening of single cells

Analyst, 2023, Accepted Manuscript
DOI: 10.1039/D3AN00902E, Paper
Tanveer Ahmed Shaik, Anuradha Ramoji, Nils Milis, Jürgen Popp, Christoph Krafft
Major drawbacks of direct mid-infrared spectroscopic imaging of single cells in aqueous buffer are strong water absorption, low resolution typically above 10 µm, and Mie scattering effects. This study demonstrates...
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Rapid sub-nanomolar protein determination in serum using electropolymerized molecularly imprinted polymers (E-MIPs)

Analyst, 2023, Advance Article
DOI: 10.1039/D3AN01498C, Paper
Open Access Open Access
A. N. Stephen, S. R. Dennison, M. A. Holden, S. M. Reddy
Electropolymerized MIP (E-MIP) on disposable electrode for rapid and quantitative sub-nanomolar protein determination in serum using electrochemical impedance spectroscopy. Simple and rapid KD determination for E-MIP.
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A ratiometric SERS sensor with one signal probe for ultrasensitive and quantitative monitoring of serum xanthine

Analyst, 2023, Advance Article
DOI: 10.1039/D3AN01245J, Paper
Yan Wu, Rongnan Yi, Honghui Zang, Jing Li, Rong Xu, Fang Zhao, Junli Wang, Cuicui Fu, Jinyang Chen
A ratiometric SERS sensor for sensitive, rapid, and reliable detection of serum xanthine has been proposed.
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Designing stimuli-responsive upconversion nanoparticles based on a mimetic immunoassay for potential accurate diabetic nephropathy diagnosis

Analyst, 2023, Advance Article
DOI: 10.1039/D3AN01041D, Paper
Yiting Wang, Yang Hu, Ru Wang, Wei Zhang, Huiting Mao, Chuanjun Yuan, Ruinian Hua
An ultrasensitive non-proteinuria assay platform to accurately diagnose DN within 20 min based on the mimetic immunoassay.
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Light-up split aptamers: binding thermodynamics and kinetics for sensing

Analyst, 2023, Advance Article
DOI: 10.1039/D3AN01368E, Paper
Yichen Zhao, Nikesh Patel, Peihuan Sun, Karen Faulds, Duncan Graham, Juewen Liu
Using a light-up aptamer that can bind doxycycline, the binding thermodynamics and kinetics of the full-length aptamer and a series of split aptamers are compared.
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Background free in vivo 29Si MR imaging with hyperpolarized PEGylated silicon nanoparticles

Analyst, 2023, Advance Article
DOI: 10.1039/D3AN01395B, Communication
Seung-Hyun Yang, Jiwon Kim, Tae Geol Lee, Mirae Park, Hye Young Son, Chan Gyu Joo, Jeong Hyun Shim, Youngbok Lee, Yong-Min Huh
This research highlights in vivo significance of 50 nm PEGylated Si NPs, which were confirmed by obtaining satisfactory hyperpolarized 29Si MR images.
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