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Dual-responsive PEG-lipid polyester nanoparticles (PEG BR647-NPs) were employed as a vaccine and STAT3 siRNA carrier for tumor-targeted delivery to modulate the tumor microenvironment.
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Open Access

  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

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The therapeutic efficacy of nanomedicines is highly dependent on their access to target sites in the body, and this in turn is markedly affected by their size, shape and transport properties in tissue.
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A biodegradable COF was constructed to break in response to tumors, enhancing the therapeutic effect on tumors.
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Biomater. Sci., 2023, 11,6384-6402
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The magnetically anisotropic structure confers unique properties and promising application prospects to hydrogels in tissue engineering.
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The application of 4D printing and bioprinting in cardiovascular diseases.
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Harnessing the potential of NO-releasing ampicillin conjugate as a catheter-lock solution against antibiotic-resistant bacteria. This approach holds great potential in addressing the challenges posed by antibiotic resistance in clinical settings.
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Biomater. Sci., 2023, 11,6537-6544
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Extracellular matrix is a natural microenvironment pivotal for stem cell survival, as well as proliferation, differentiation and metastasis, composed of a variety of biological molecular complexes secreted by resident cells in tissues and organs.
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Biomater. Sci., 2023, 11,6492-6503
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Despite exquisite immune response modulation, the extensive application of microRNA therapy in treating heart transplant rejection is still impeded by poor stability and low target efficiency.
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Biomater. Sci., 2023, 11,6906-6918
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Wen-Xin Zhang, You Li, Di Ke, Yi-Ru Gao, Teng Fei, Guo-Qing Wang, Yang Shu, Jian-Hua Wang
Ferroptosis is a non-apoptotic form of regulated cell death.
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Biomater. Sci., 2023, 11,6611-6618
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Xuan Yi, Pengqi Wan, Wei Shen, Xiaonong Zhang, Peng Zhang, Chunsheng Xiao
A cationic lipo-polylysine C₁₂-PLL₁₃ can interact with negatively charged tumor cell membrane and induce cell necrosis by triggering membrane perforation and disintegration, offering a distinct therapeutic mechanism from traditional antitumor drugs.
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