Formulation and evaluation of anion transporters in nanostructured lipid carriers

Org. Biomol. Chem., 2023, 21,7753-7757
DOI: 10.1039/D3OB01182H, Paper
Open Access Open Access
Daniel Alonso-Carrillo, Israel Carreira-Barral, Marcin Mielczarek, Andrea Sancho-Medina, Enara Herran, Claudia Vairo, Angel Del Pozo, Iris Luzuriaga, Nerea Lazcanoiturburu, Oihane Ibarrola, Sara Ponce, María Villar-Vidal, María García-Valverde, Roberto Quesada
Nanostructured lipid carriers (NLCs) can be used to efficiently formulate highly lipophilic anionophores. These formulations are able to deliver these compounds to phospholipid membranes maintaining their anion transport activity.
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Butterflyene: an entry into an aesthetically pleasing carbocycle via a Diels–Alder reaction on a tetrasubstituted olefin

Org. Biomol. Chem., 2023, 21,7917-7923
DOI: 10.1039/D3OB01056B, Paper
Gaurang J. Bhatt, Pradeep T. Deota, Narayan N. Som, Darshil Shah
An aesthetically pleasing prototype decacyclic ring system resembling the shape of a butterfly has been synthesized in four simple steps. Diels–Alder reactions on a tetrasubstituted double bond give rise to the formation of its analogues.
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Phosphine-catalyzed ring-opening reaction of cyclopropenones with dicarbonyl compounds

Org. Biomol. Chem., 2023, 21,7712-7716
DOI: 10.1039/D3OB01409F, Communication
Chen Liang, Zhibin Chen, Xinyue Hu, Shengxia Yu, Zhenlian Wang, Jiang Cheng
We developed a phosphine-catalyzed ring-opening reaction of cyclopropenones with dicarbonyl compounds as C-nucleophiles, leading to 1,3,3′-tricarbonyl compounds.
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The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe

Org. Biomol. Chem., 2023, 21,7813-7820
DOI: 10.1039/D3OB01261A, Paper
Chi-Lin Kuo, Qin Su, Adrianus M. C. H. van den Nieuwendijk, Thomas J. M. Beenakker, Wendy A. Offen, Lianne I. Willems, Rolf. G. Boot, Alexi J. Sarris, André R. A. Marques, Jeroen D. C. Codée, Gijsbert A. van der Marel, Bogdan I. Florea, Gideon J. Davies, Herman S. Overkleeft, Johannes M. F. G. Aerts
Acid β-galactosidase (GLB1) and galactocerebrosidase (GALC) are retaining exo-β-galactosidases involved in lysosomal glycoconjugate metabolism.
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A reaction-based scenario for fluorescence probing of Au(III) ions in human cells and plants

Org. Biomol. Chem., 2023, 21,7880-7885
DOI: 10.1039/D3OB01081C, Communication
Merve Çevik Eren, Ahmet Eren, Suay Dartar, Beraat Umur Kaya, Muhammed Üçüncü, Canan Varlikli, Hüseyin Çağlar Karakaya, Mustafa Emrullahoğlu
In the presence of gold ions, a BODIPY construct with an extended π-conjugation transforms into a new structure with a relatively short π-system, which can be monitored as distinct changes in the color of the emission in plants and human cells.
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Cell internalization kinetics and surface charge accessibility of surface-modified PAMAM dendrimers

Org. Biomol. Chem., 2023, 21,7782-7790
DOI: 10.1039/D3OB01265D, Paper
Carola F. Díaz, Diego L. Cifuentes, Maximiliano Oyarzún, Verónica A. Jiménez, Leonardo Guzmán
The accessibility of surface cationic charges is a key determinant for the cell internalization capacity of surface-modified PAMAM dendrimers with acetyl, folate or poly(ethylene glycol) groups.
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Tunable full-color emission of stilbazoles containing a 2-halo-3,4-dicyanopyridine acceptor

Org. Biomol. Chem., 2023, 21,7935-7943
DOI: 10.1039/D3OB01326J, Paper
Anastasia I. Ershova, Sergey V. Fedoseev, Sergey A. Blinov, Mikhail Yu. Ievlev, Konstantin V. Lipin, Oleg V. Ershov
Synthesis of a series of novel push–pull stilbazole-based chromophores with tunable multicolor emission ranging from 442 nm to 710 nm and covering the whole visible spectrum is reported.
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Recent advances in computational studies on Cu-catalyzed aerobic reactions: cooperation of copper catalysts and dioxygen

Org. Biomol. Chem., 2023, 21,7852-7872
DOI: 10.1039/D3OB00976A, Review Article
Yuan-Ye Jiang, Chao Chen
This review summarizes the advances in computational studies on Cu-catalyzed aerobic reactions and focuses on the cooperation mechanisms of copper complexes and dioxygen.
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Overlooked aza-S(IV) motifs: synthesis and transformations of sulfinamidines and sulfinimidate esters

Org. Biomol. Chem., 2023, 21,7681-7690
DOI: 10.1039/D3OB01382K, Review Article
Michael Andresini, Marco Colella, Leonardo Degennaro, Renzo Luisi
Significant advancements have recently been made in the chemistry of sulfinamidines and sulfinimidate esters. This review aims to provide an overview of the synthetic methods for the preparation and transformation of these overlooked compounds.
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Synthesis of 1,3-disubstituted bicyclo[1.1.1]pentanes by cross-coupling induced by transition metals – formation of C–C bonds

Org. Biomol. Chem., 2023, 21,7666-7680
DOI: 10.1039/D3OB01036H, Review Article
Tomohiro Yasukawa, Katja S. Håheim, Janine Cossy
The synthesis of 1,3-disubstituted bicyclo[1.1.1]pentanes (BCPs), by forming a C–C bond, can be achieved by cross-coupling reaction using transition metal catalysts.
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