Branched montbretin A mimics allow derivatisation and potent amylase inhibition

Org. Biomol. Chem., 2023, 21,7977-7983
DOI: 10.1039/D3OB01051A, Paper
Matthew Calvert, Ryan P. Sweeney, Hong-Ming Chen, Harbir Bajwa, Seyed A. Nasseri, Davood Habibi, Stephen G. Withers
Structure-based design of a branched version of a high affinity amylase inhibitor based on the natural product montbretin A allows derivatization and manipulation of physical properties while retaining potent (nM) inhibition.
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Sequential detection of inflammation-related hypochlorite ions and viscosity with a relay fluorescent probe

Org. Biomol. Chem., 2023, 21,7808-7812
DOI: 10.1039/D3OB00967J, Paper
Yu-Qing Zhang, Zhi-Nan Kang, Jing-Jie Ming, Sheng-Nan Suo, Jia-Ling Kang, Hai Xu, Ya-Wen Wang, Yu Peng
A new fluorescent probe has been developed for relay detection of hypochlorite ions and viscosity.
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Lactam-fused tropolones: a new tunable, environmentally sensitive fluorophore class

Org. Biomol. Chem., 2023, 21,7900-7907
DOI: 10.1039/D3OB01263H, Communication
Daniel V. Schiavone, Joel Gallardo, Diana M. Kapkayeva, John-Charles Baucom, Ryan P. Murelli
Lactam-fused tropolones are easily accessible, environmentally-responsive fluorophores with broad emissions profiles.
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Recent progress in photoinduced direct desulfurization of thiols

Org. Biomol. Chem., 2023, 21,7873-7879
DOI: 10.1039/D3OB01274C, Review Article
Yuhong Ma, Jinfei Deng, Jianyu Gu, Dengbo Jiang, Kaizhuo Lv, Xiushen Ye, Qiuli Yao
Light-driven desulfurization and coupling reactions of mercaptans in the modification of glycosides, proteins, polymers, and deuterated compounds are reviewed.
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Electrochemical selenium-catalyzed para-amination of N-aryloxyamides: access to polysubstituted aminophenols

Org. Biomol. Chem., 2023, 21,7895-7899
DOI: 10.1039/D3OB01116J, Communication
Lei Gao, Zhi-Feng Wang, Lin-Wei Wang, Hai-Tao Tang, Zu-Yu Mo, Mu-Xue He
We have developed a mild method for selenium catalyzed intramolecular rearrangement of N-aryloxyamides to produce para amination products under electrochemical conditions. The method has the advantages of high efficiency, high atom utilization and environmental friendliness.
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Multicomponent cyclization with azides to synthesize N-heterocycles

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01115A, Review Article
Hong Guo, Bei Zhou, Jingjing Chang, Wenxu Chang, Jiyao Feng, Zhenhua Zhang
The review focus on multicomponent reactions of azides for the construction of N-heterocycles in recent 10 years.
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InCl3-catalyzed intramolecular carbonyl–olefin metathesis

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01170D, Paper
Marianela G. Pizzio, Zoe B. Cenizo, Luciana Méndez, Ariel M. Sarotti, Ernesto G. Mata
We describe a novel synthetic strategy for intramolecular carbonyl–olefin metathesis based on InCl3 catalysis and a sustainably attractive protocol.
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Visible-light-promoted organic-dye-catalyzed sulfonylation/cyclization to access indolo[2,1-a]isoquinoline derivatives

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01289A, Paper
Yucai Tang, Jinglin Duan, Biyu Yang, Yupeng He, Changyuan Du, Xiangyang Zhang
An efficient visible-light-promoted organic-dye-catalyzed radical cascade cyclization was developed for the rapid synthesis of sulfonyl-substituted indolo[2,1-a]isoquinolines and benzimidazo[2,1-a]isoquinolin-6(5H)-ones.
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A kinetics study of copper-catalysed click reactions in ionic liquids

Org. Biomol. Chem., 2023, 21,7984-7993
DOI: 10.1039/D3OB00237C, Paper
Diana Sloboda, Cameron C. Weber, Eduards Bakis
In this study, we discovered that both the structure of the ionic liquid and the catalyst exert a significant influence on the copper(I)-catalyzed azide–alkyne cycloaddition reaction rate.
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A turn-on fluorescent probe for selective detection of H2S in environmental samples and bio-imaging in human breast cancer cells

Org. Biomol. Chem., 2023, 21,8020-8030
DOI: 10.1039/D3OB01319G, Paper
Dipanjan Banik, Anirban Karak, Satyajit Halder, Shilpita Banerjee, Moumi Mandal, Anwesha Maiti, Kuladip Jana, Ajit Kumar Mahapatra
A turn-on fluorescent probe TPB-NO2 was synthesized for rapid detection of H2S in environmental and biological samples. A bright cyan colour was observed due to the PET mechanism.
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