Volume 199, Issue 2, 2024, Page 178-186
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Resolving D-Amino Acid Containing Peptides Using Ion Mobility-Mass Spectrometry: Challenges and Recent Developments
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Rh(I)-catalyzed enantioselective (3 + 2) transannulations of 1,2,3-thiadiazoles with P-chiral monodentate phosphines
Facile synthesis of new thiazinanones derived by acenaphythylenone
Visible light photoredox-catalyzed phosphorylation of α-bromostyrenes: a mild synthesis of β-ketophosphine oxides
STEM Structural Investigation of RE‐Au‐Si 1/1 Approximants
Abstract
RE-Au-Si (RE=Ho, Tb) systems are 1/1 Tsai-type quasicrystalline approximants with a cluster center decoration that can vary from a disordered tetrahedron to a rare-earth atom. The local atomic structure of three different samples was observed by scanning transmission electron microscopy and interpreted in the light of high-angle annular dark field simulated scanning transmission electron microscopy images. It is found that the combination of these two methods allows to identify differences in the chemical decoration of the cluster centers through quantitative analysis of line profiles.
Modeling stages of domino reaction of thiopyrano[4,3-b]indole-3(5H)-thiones and dimethyl acetylenedicarboxylate: a new synthetic route to γ-carbolines with thione group
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Divergent decomposition pathways of DMSO mediated by solvents and additives
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CZTS (Cu2ZnSnS4)‐based Nanomaterials in Photocatalytic and Hydrogen Production Applications: A Recent Progress towards Sustainable Environment
The illustrative description for the synthesis method of CZTS and their distinctive morphological effects are explained in this review. The potential scope of CZTS utilization in wastewater-cleaning through photocatalytic dye-degradation is thoroughly narrated. A comparative analysis of CZTS nanocomposites is provided to indicate its future prospective as a promising material for hydrogen evolution, thus motivating researchers to investigate in this new direction.
Abstract
A variety of unique compounds have been examined to accommodate the current demand for useful multi-functional nanomaterials, copper-based quaternary CZTS semiconductors are one of them. Due to their special characteristic features like non-toxicity, cheap, and abundance, they have been recommended in recent literature for various applications. Apart from individual CZTS, different hetero-structures have also been prepared with different compounds which is well discussed and elaborated in this article. Additionally, their preparation methods, properties, and application viability have also been discussed comprehensively. The application of CZTS such as photocatalytic dye degradation and hydrogen evolution reaction has been elaborated on in this article identifying their benefits and challenges to give readers a thorough visualization. Apart from that, challenges reported in studies, a few approaches are also mentioned to possibly counter them.
Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation
Abstract
The NLRP3 inflammasome is a cytosolic protein complex that regulates innate immune signaling in response to diverse pathogenic insults through the proteolytic processing and secretion of pro-inflammatory cytokines such as IL-1β. Hyperactivation of NLRP3 inflammasome signaling is implicated in the onset and pathogenesis of numerous diseases, motivating the discovery of new strategies to suppress NLRP3 inflammasome activity. We sought to define the potential for the proteostasis regulator AA147 to inhibit the assembly and activation of the NLRP3 inflammasome. AA147 is a pro-drug that is metabolically converted to a reactive metabolite at the endoplasmic reticulum (ER) membrane to covalently modify ER-localized proteins such as protein disulfide isomerases (PDIs). We show that AA147 inhibits NLRP3 inflammasome activity in monocytes and monocyte-derived macrophages through a mechanism involving impaired assembly of the active inflammasome complex. This inhibition is mediated through AA147-dependent covalent modification of PDIA1. Genetic depletion or treatment with other highly selective PDIA1 inhibitors similarly blocks NLRP3 inflammasome assembly and activation. Our results identify PDIA1 as a potential therapeutic target to mitigate NLRP3 inflammasome-mediated pro-inflammatory signaling implicated in etiologically diverse diseases.