Publication date: November 2023
Source: FlatChem, Volume 42
Author(s): Omar Alami, Régis Laurent, Marine Tassé, Yannick Coppel, Vincent Collière, Jérôme Bignon, Jean-Pierre Majoral, Saïd El Kazzouli, Nabil El Brahmi, Anne-Marie Caminade
2D/2D cobalt vanadate nanoplatelets/S-doped reduced graphene oxide nanosheets composite for the detection of nonsteroidal anti-inflammatory drug: Acetaminophen
Publication date: November 2023
Source: FlatChem, Volume 42
Author(s): Saranvignesh Alagarsamy, Kiruthika Mariappan, Shen-Ming Chen, Rasu Ramachandran, Sandhanasamy Devanesan, Mohamad S. AlSalhi, Prabhakarn Arunachalam, Dhanushkodi Sivaganesh, Jeyaraj Vinoth Kumar, Hsin-Yu Chuang
Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Mbilo Misehe, Marika Matoušová, Alexandra Dvořáková, Kamil Hercík, Kryštof Škach, Dominika Chalupská, Milan Dejmek, Michal Šála, Miroslav Hájek, Evzen Boura, Helena Mertlíková-Kaiserová, Radim Nencka
Design, synthesis and evaluation of 2-pyrimidinylindole derivatives as anti-obesity agents by regulating lipid metabolism
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Shi-Yao Guo, Li-Yuan Wei, Bing-Bing Song, Yu-Tao Hu, Zhi Jiang, Dan-Dan Zhao, Yao-Hao Xu, Yu-Wei Lin, Shu-Min Xu, Shuo-Bin Chen, Zhi-Shu Huang
Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Sara Elsayed, Ahmed S. Abdelkhalek, Samar Rezq, Mansour E. Abu Kull, Damian G. Romero, Hend Kothayer
Discovery of X10g as a selective PROTAC degrader of Hsp90α protein for treating breast cancer
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Qingna Jiang, Minghai Fu, Yuanling Tang, Ge Li, Guihui Tu, Xinhua Wu, Qiurong Wu, Xiuwang Huang, Jianhua Xu, Yang Liu, Lixian Wu
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of 4-butyl-polyhydroxybenzophenone compounds against NAFLD
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Jiayu Song, Luyao Ren, Zhenzhu Ren, Xing Ren, Yang Qi, Yuxi Qin, Xiaohui Zhang, Yuan Ren, Yunlan Li
Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Davide Moi, Davide Bonanni, Silvia Belluti, Pasquale Linciano, Andrea Citarella, Silvia Franchini, Claudia Sorbi, Carol Imbriano, Luca Pinzi, Giulio Rastelli
Discovery of antiviral SARS-CoV-2 main protease inhibitors by structure-guided hit-to-lead optimization of carmofur
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Koon Mook Kang, Yejin Jang, Sang Soo Lee, Mi Sun Jin, Chang-Duk Jun, Meehyein Kim, Yong-Chul Kim
Lead generation from <em>N</em>-[benzyl(4-phenylbutyl)carbamoyl]amino acid as a novel LPA<sub>1</sub> antagonist for the treatment of systemic sclerosis
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Yuki Kobayashi, Fumito Uneuchi, Takumi Naruse, Daisuke Matsuda, Lisa Okumura-Kitajima, Hiromitsu Kajiyama, Reiko Wada, Yuki Yonemoto, Koichiro Nakano, Hidetoh Toki, Shunsuke Kamigaso, Jyunya Yamagishi, Seiken Tokura, Hiroyuki Kakinuma, Shoichi Kuroda