Design of phenothiazine-based cationic amphiphilic derivatives incorporating arginine residues: Potential membrane-active broad-spectrum antimicrobials combating pathogenic bacteria in vitro and in vivo

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Qian Yu, Qiongna Cai, Wanxin Liang, Kewen Zhong, Jiayong Liu, Haizhou Li, Yongzhi Chen, Hongxia Li, Shanfang Fang, Rongcui Zhong, Shouping Liu, Shuimu Lin

Cantharidin analogue alleviates dextran sulfate sodium-induced colitis in mice by inhibiting the activation of NF-κB signaling

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Yihang Wu, Zixiu Liu, Zhenxiu He, Jumei Yi, Xingfang Qiao, Chunbin Tan, Yajing Xing, Yaobo Zeng, Dajian Yang, Junlin Yin, Baomin Fan, Guangzhi Zeng

Synthesis and evaluation of 2-NMPA derivatives as potential agents for prevention of osteoporosis <em>in vitro</em> and <em>in vivo</em>

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Zhihao Chen, Devaneyan Joseph, Mina Ding, Swapnil Pandurang Bhujbal, Robin Prakash Sirvin Rajan, Eunae Kim, Sang-wook Park, Sunwoo Lee, Tae-Hoon Lee

Synthesis of 1,3,5-triphenyl-1,2,4-triazole derivatives and their neuroprotection by anti-oxidative stress and anti-inflammation and protecting BBB

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Yang Wang, Ruiqi Su, Jianwen Chen, Xuan Liu, Jingning Luo, Yaoqiang Lao, Ping Huang, Jinguo Shi, Caibao Jiang, Liping Liao, Jingxia Zhang

Design, synthesis and evaluation of novel pyrimidinylaminothiophene derivatives as FGFR1 inhibitors against human glioblastoma multiforme

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Yong-Liang Li, Long-Jia Yan, Hui-Xiong Chen, Ban-Kang Ruan, Pascal Dao, Zhi-Yun Du, Chang-Zhi Dong, Bernard Meunier

Hydrophobicity modulation <em>via</em> the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer’s disease for potent serotonin 5-HT<sub>6</sub>R agents

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Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Sylwia Sudoł-Tałaj, Katarzyna Kucwaj-Brysz, Sabina Podlewska, Rafał Kurczab, Grzegorz Satała, Barbara Mordyl, Monika Głuch-Lutwin, Natalia Wilczyńska-Zawal, Magdalena Jastrzębska-Więsek, Kinga Czarnota-Łydka, Kinga Kurowska, Monika Kubacka, Ewa Żesławska, Wojciech Nitek, Agnieszka Olejarz-Maciej, Agata Doroz-Płonka, Anna Partyka, Gniewomir Latacz, Anna Wesołowska, Jadwiga Handzlik