Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Ana Novak, Florian Kersaudy, Sylvie Berger, Séverine Morisset-Lopez, François Lefoulon, Carlo Pifferi, Vincent Aucagne
Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Rajeshwar Narlawar, Lutgarde Serneels, Celia Gaffric, Harrie J.M. Gijsen, Bart De Strooper, François Bischoff
Computational methods to analyze and predict the binding mode of inhibitors targeting both human and mushroom tyrosinase
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Federico Ricci, Kristina Schira, Lyna Khettabi, Lisa Lombardo, Salvatore Mirabile, Rosaria Gitto, Montserrat Soler-Lopez, Jörg Scheuermann, Gerhard Wolber, Laura De Luca
Synthesis of cannabidiol-based compounds as ACE2 inhibitors with potential application in the treatment of COVID-19
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Gabriel Vitor de Lima Marques, Daisymara Priscila de Almeida Marques, Felipe Alves Clarindo, Jesus Alberto Avendaño-Villarreal, Fabiana Sélos Guerra, Patrícia Dias Fernandes, Eduardo Nicolau dos Santos, Elena Vitalievna Gusevskaya, Markus Kohlhoff, Fabrício de Araújo Moreira, Luis Adan Flores Andrade, Flávio Guimarães da Fonseca, Jordana Grazziela Alves Coelho dos-Reis, Renata Barbosa de Oliveira
Pyrrole-thiazolidinone hybrids as a new structural class of broad-spectrum anti-infectives
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Shujauddin Ahmed, Alka Mital, Abdul Akhir, Deepanshi Saxena, Mohammad Naiyaz Ahmad, Arunava Dasgupta, Sidharth Chopra, Rahul Jain
Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Zhijie Wang, Donglin Wu, Xiaofei Zhao, Canlin Liu, Siming Jia, Qindi He, Fei Huang, Zitian Cheng, Tao Lu, Yadong Chen, Yun Chen, Pei Yang, Shuai Lu
Novel ProTide prodrugs of 5-fluoro-2′-deoxyuridine for the treatment of liver cancer
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Leilei Jiang, Ting Pan, Qin Lv, Wenmin Yuan, Xiaochun Liu, Xianjun Qu, Dongdong Luo, Shengbiao Wan, Shuxiang Cui
Tetrahydro-<em>β</em>-carboline derivatives as potent histone deacetylase 6 inhibitors with broad-spectrum antiproliferative activity
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Xin Chen, Jiayun Wang, Peng Zhao, Baiyun Dang, Ting Liang, Raphael R. Steimbach, Aubry K. Miller, Jia Liu, Xin Wang, Tongtong Zhang, Xiaofa Luan, Jiadong Hu, Jinming Gao
Novel spiro[pyrrolidine-2,3′-quinoline]-2′-one derivatives containing piperazine fragment as potential chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Lige Liu, Hu Wu, Yan Long, Xinlong Yang, Chuanbiao Du, Yajie Xu, Qinggang Ji
Podophyllotoxin-loaded PEGylated E-selectin peptide conjugate targeted cancer site to enhance tumor inhibition and reduce side effect
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Cen Xiang, Ying Fu, Tiantian Hao, Linlin Wei, Yuning Liu, Zhen-Chuan Fan, Na Guo, Peng Yu, Yu-ou Teng