Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Xue-Mei Zhou, Qian-Yue Li, Xing Lu, Rammohan R.Yadav Bheemanaboina, Bo Fang, Gui-Xin Cai, Cheng-He Zhou
Synthesis of peptidomimetics as antibiotic adjuvants for combination with aztreonam to combat MDR <em>Pseudomonas aeruginosa</em>
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Xican Ma, Wei Guo, Xi Zhu, Zhiwen Li, Yinghong Li, Zhihao Guo, Yanxiang Wang, Jing Pang, Min Yuan, Zhenjun Li, Xuefu You, Xi Lu, Yishuang Liu, Danqing Song
Discovery of NLRP3 inhibitors using machine learning: Identification of a hit compound to treat NLRP3 activation-driven diseases
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Cheng Shi, Xiangyu Zhang, Xiaowei Chi, Yi Ran Zhou, Weiping Lyu, Tongfei Gao, Jiaxu Zhou, Yanming Chen, Chuxiao Yi, Xiaojiao Sun, Liangren Zhang, Zhenming Liu
Anti-influenza virus activities and mechanism of antrafenine analogs
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Yun-Sang Tang, Chao Zhang, Chun-Yeung Lo, Zhe Jin, Bobby Lim-Ho Kong, Meng-Jie Xiao, Er-Fang Huang, Chun Hu, Pang-Chui Shaw
Optimization and antifungal activity of quinoline derivatives linked to chalcone moiety combined with FLC against <em>Candida albicans</em>
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Aimei Sun, Nannan Chai, Xianhu Zhu, Yanping Li, Ruirui Wang, Yi Zhang, Zewei Mao
Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Tizhi Wu, Zhiming Zhang, Guangyue Gong, Zekun Du, Yifan Xu, Sixian Yu, Feihai Ma, Xuan Zhang, Yuxiao Wang, Haoming Chen, Shiqi Wu, Xi Xu, Zhixia Qiu, Zhiyu Li, Hongxi Wu, Jinlei Bian, Jubo Wang
Discovery of novel isopropanolamine inhibitors against <em>Mo</em>TPS1 as potential fungicides with unique mechanisms
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Zhiyang Jiang, Dongmei Shi, Yitong Chen, Huilin Li, Jin'e Wang, Xinrui Lv, Yunjiang Zi, Dongli Wang, Zhijian Xu, Jiaxing Huang, Junfeng Liu, Hongxia Duan
Design, synthesis and evaluation of ursodeoxycholic acid-cinnamic acid hybrids as potential anti-inflammatory agents by inhibiting Akt/NF-κB and MAPK signaling pathways
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Xiaoxue Li, Yue Hu, Bingxin He, Lingyu Li, Yu Tian, Yingjie Xiao, Hai Shang, Zhongmei Zou
Discovery of novel benzofuran-based derivatives as acetylcholinesterase inhibitors for the treatment of Alzheimer’s disease: Design, synthesis, biological evaluation, molecular docking and 3D-QSAR investigation
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Somaia S. Abd El-Karim, Manal M. Anwar, Nesreen S. Ahmed, Yasmin M. Syam, Samia A. Elseginy, Hanan F. Aly, Eman A. Younis, Wagdy K.B. Khalil, Kawkab A. Ahmed, Faten F. Mohammed, Maha Rizk
Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for μ Opioid receptor for Safer and long-lasting analgesia
Publication date: 15 November 2023
Source: European Journal of Medicinal Chemistry, Volume 260
Author(s): Andrea Angeli, Laura Micheli, Rita Turnaturi, Lorella Pasquinucci, Carmela Parenti, Vincenzo Alterio, Anna Di Fiore, Giuseppina De Simone, Simona Maria Monti, Fabrizio Carta, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Claudiu T. Supuran