Rapid access to icetexane diterpenes: Their protective effects against lipopolysaccharides-induced acute lung injury <em>via</em> PI3K/AKT/NF-κB axis in macrophages

Posted on by

Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Moude Liu, Qin Tang, Qing Wang, Weixi Xie, Jinbao Fan, Siyuan Tang, Wei Liu, Yingjun Zhou, Xu Deng

Discovery of Pyrazolo[1,5-<em>a</em>]pyrimidine derivative as a potent and selective PI3Kγ/δ dual inhibitor

Posted on by

Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Xiaofei Liang, Maoqing Deng, Fengming Zou, Ziping Qi, Chun Wang, Juan Liu, Qingwang Liu, Beilei Wang, Shuang Qi, Juan Ge, Hongwei Yu, Aoli Wang, Qingsong Liu, Jing Liu

Design, synthesis and antitrypanosomatid activity of 2-nitroimidazole-3,5-disubstituted isoxazole compounds based on benznidazole

Posted on by

Publication date: 15 November 2023

Source: European Journal of Medicinal Chemistry, Volume 260

Author(s): Diego B. Carvalho, Pedro A.N. Costa, Gisele B. Portapilla, Amarith R. das Neves, Cristiane Y.K. Shiguemoto, Bruno I. Pelizaro, Fernanda Silva, Eliane M. Piranda, Carla C.P. Arruda, Priscyla D.M. Gaspari, Iara A. Cardoso, Pedro H. Luccas, M. Cristina Nonato, Norberto P. Lopes, Sergio de Albuquerque, Adriano C.M. Baroni