Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Lu Ma, Menglong Li, Yueteng Zhang, Kangdong Liu
Identification of 1,3,4-oxadiazolyl-containing β-carboline derivatives as novel α-glucosidase inhibitors with antidiabetic activity
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Di Xiao, Li Lu, Bingwen Liang, Zhuang Xiong, Xuetao Xu, Wen-Hua Chen
Synthesis of bitopic ligands based on fallypride and evaluation of their affinity and selectivity towards dopamine D<sub>2</sub> and D<sub>3</sub> receptors
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Gui-Long Tian, Chia-Ju Hsieh, Michelle Taylor, Ji Youn Lee, Aladdin A. Riad, Robert R. Luedtke, Robert H. Mach
Identification of novel dithiocarbamate-copper complexes targeting p97/NPL4 pathway in cancer cells
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Martin Loffelmann, Zdeněk Škrott, Dušana Majera, Pavel Štarha, Vladimír Kryštof, Martin Mistrík
Novel chlorin e<sub>6</sub>-based conjugates of tyrosine kinase inhibitors: Synthesis and photobiological evaluation as potent photosensitizers for photodynamic therapy
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Fei Huang, Yu Li, Xing-Jie Zhang, Mei-Yu Lin, Gui-Yan Han, Hui-Ying Lin, Hui-Yun Lin, Zhenyuan Miao, Bu-Hong Li, Chun-Quan Sheng, Jian-Zhong Yao
The design, synthesis, and inhibition of <em>Clostridioides difficile</em> spore germination by acyclic and bicyclic tertiary amide analogs of cholate
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Shiv K. Sharma, Angel R. Schilke, Jacqueline R. Phan, Christopher Yip, Prateek V. Sharma, Ernesto Abel-Santos, Steven M. Firestine
Synthesis and mechanism of action of new purine derivatives against triple negative breast cancer
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Qian Zhang, Guoyang Sun, Yuna Huang, Shanshan Cui, Tingshen Li, Lianbo Zhao, Kui Lu, Peng Yu, Yongmin Zhang, Herve Galons, Nassima Oumata, Yuou Teng
Fragment-based and structure-guided discovery of perforin inhibitors
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Jiney Jose, Ruby H.P. Law, Eleanor W.W. Leung, Dorothy C.C. Wai, Hedieh Akhlaghi, Indu R. Chandrashekaran, Tom T. Caradoc-Davies, Ilia Voskoboinik, John Feutrill, David Middlemiss, Devadharshini Jeevarajah, Tanya Bashtannyk-Puhalovich, Anna C. Giddens, Tet Woo Lee, Stephen M.F. Jamieson, Joseph A. Trapani, James C. Whisstock, Julie A. Spicer, Raymond S. Norton
A dipyridophenazine Ni(II) dithiolene complex as a dual-acting cancer phototherapy agent activatable within the phototherapeutic window
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Tukki Sarkar, Somarupa Sahoo, Suditi Neekhra, Milan Paul, Swati Biswas, Bathini Nagendra Babu, Rohit Srivastava, Akhtar Hussain
Discovery of 1,2-diaryl-3-oxopyrazolidin-4-carboxamides as a new class of MurA enzyme inhibitors and characterization of their antibacterial activity
Publication date: 5 December 2023
Source: European Journal of Medicinal Chemistry, Volume 261
Author(s): Reem A. Wagdy, Nader S. Abutaleb, Reem K. Fathalla, Yehia Elgammal, Stefanie Weck, Rusha Pal, Patrick D. Fischer, Christian Ducho, Ashraf H. Abadi, Mohamed N Seleem, Matthias Engel, Mohammad Abdel-Halim