Development of chalcone-like derivatives and their biological and mechanistic investigations as novel influenza nuclear export inhibitors

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Publication date: 5 December 2023

Source: European Journal of Medicinal Chemistry, Volume 261

Author(s): Chuanfeng Liu, Ying Zhang, Ping Li, Huinan Jia, Han Ju, Jiwei Zhang, Edeildo Ferreira da Silva-Júnior, Sunanda Samanta, Parimal Kar, Bing Huang, Xinyong Liu, Peng Zhan

Synthesis of novel rhodamine type Anthrone Spiro-lactam (ASL) analogues and evaluation of antiviral activity against dengue and chikungunya viruses

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Publication date: 5 December 2023

Source: European Journal of Medicinal Chemistry, Volume 261

Author(s): Ratanamala S. Darole, Pooja K. Bagad, Rajesh G. Gonnade, Kalichamy Alagarasu, Madhura Punekar, Shridhar Shukla, Deepti Parashar, Beeran Senthilkumar

Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives

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Publication date: 5 December 2023

Source: European Journal of Medicinal Chemistry, Volume 261

Author(s): Emiliano Rosatelli, Andrea Carotti, Bruno Cerra, Francesca De Franco, Daniela Passeri, Roberto Pellicciari, Antimo Gioiello

Non-peptidic immunoproteasome β5i-selective inhibitor as potential treatment for idiopathic pulmonary fibrosis: Virtual screening, hit evolution and lead identification

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Publication date: 5 December 2023

Source: European Journal of Medicinal Chemistry, Volume 261

Author(s): Yunxuan Li, Guanglei Nan, Xianxin Hou, Yechao Yan, Yajun Yang, Ying Yang, Ke Li, Zhiyan Xiao

Exploring the structural-activity relationship of hexahydropyrazino[1,2-d]pyrido[3,2-b][1,4]oxazine derivatives as potent and orally-bioavailable PARP7 inhibitors

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Publication date: 5 December 2023

Source: European Journal of Medicinal Chemistry, Volume 261

Author(s): Silong Zhang, Yu Zhang, Ziwei Wang, Luolong Qing, Shaojuan Fu, Juan Xu, Yuanyuan Li, Huaxiang Fang, Huan He

Indirubin derivatives as bifunctional molecules inducing DNA damage and targeting PARP for the treatment of cancer

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Publication date: 5 December 2023

Source: European Journal of Medicinal Chemistry, Volume 261

Author(s): Siyuan Wan, Xinye Chen, Fucheng Yin, Shang Li, Yonglei Zhang, Heng Luo, Zhongwen Luo, Ningjie Cui, Yifan Chen, Xinxin Li, Lingyi Kong, Xiaobing Wang

Design, synthesis, and biological evaluation of novel 4,4′-bipyridine derivatives acting as CDK9-Cyclin T1 protein-protein interaction inhibitors against triple-negative breast cancer

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Publication date: 5 December 2023

Source: European Journal of Medicinal Chemistry, Volume 261

Author(s): Guiping Gao, Jiayi Li, Yin Cao, Xudan Li, Yuqing Qian, Xiumei Wang, Mengyu Li, Yingkun Qiu, Tong Wu, Liqiang Wang, Meijuan Fang

PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties

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Publication date: 5 December 2023

Source: European Journal of Medicinal Chemistry, Volume 261

Author(s): Francisca Pinheiro, Nathalia Varejão, Adrià Sánchez-Morales, Filipa Bezerra, Susanna Navarro, Adrián Velázquez-Campoy, Félix Busqué, Maria Rosário Almeida, Ramon Alibés, David Reverter, Irantzu Pallarès, Salvador Ventura