Discovery and Characterisation of Quinazolines and 8-Azaquinazolines as NLRP3 Agonists with Oral Bioavailability in Mice

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Publication date: Available online 12 October 2023

Source: Bioorganic & Medicinal Chemistry Letters

Author(s): Daniel H. O' Donovan, David Baker, Giovanni Ciotta, Sébastien L. Degorce, Sylvain Demanze, Milly Dockerill, Leire Escudero-Ibarz, Lucy Ireland, Yumeng Mao, Martin J. Packer, James Robinson, Graeme Scarfe, Haoran Tang, Viia Valge-Archer

Discovery of <em>(E)-2-(Hydroxyimino)-N-(2 ((4methylpentyl)amino)ethyl)acetamide</em> (KR-27425) as a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase

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Publication date: Available online 12 October 2023

Source: Bioorganic & Medicinal Chemistry Letters

Author(s): Avinash G Vishakantegowda, Berehe Solomon Girmay, Jin Soo Shin, Joo-Youn Lee, Sunjoo Ahn, Young-Sik Jung

Green synthesis and anti-biofilm activities of 3,5-disubstituted isoxazoline/isoxazole-linked secondary sulfonamide derivatives on <em>Pseudomonas aeruginosa</em>

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Publication date: Available online 12 October 2023

Source: Bioorganic & Medicinal Chemistry Letters

Author(s): Ayoub El Mahmoudi, Anne-Sophie Tareau, Magalie Barreau, Sylvie Chevalier, Chaimae Hourma, Luc Demange, Rachid Benhida, Khalid Bougrin

Flexibility in the bridge of chalcone derivatives is important for the inhibition of cellular growth

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Publication date: 15 October 2023

Source: Bioorganic & Medicinal Chemistry Letters, Volume 95

Author(s): Trevor M. Stantliff, Amber Hill, Mary Elaine Kuo, Hadley E. Neal, Tighe C. Harrod, Katy Goens, Mark Mashuta, Anna M. Christianson, Amanda J. Krzysiak

Discovery of marine phidianidine-based Nrf2 activators and their potential against oxLDL- and HG-induced injury in HUVECs

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Publication date: 15 October 2023

Source: Bioorganic & Medicinal Chemistry Letters, Volume 95

Author(s): Juan Zhang, Yong-Si Cai, Hua-Long Ji, Mengqi Ma, Jin-He Zhang, Zhi-Qiang Cheng, Kai-Ming Wang, Cheng-Shi Jiang, Chunlin Zhuang, Yang Hu, Ning Meng