Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Shiwei Lu, Feng Zhang, Jiahao Gong, Jian Huang, Guanghao Zhu, Yitian Zhao, Qi Jia, Yiming Li, Bo Li, Kaixian Chen, Weiliang Zhu, Guangbo Ge
DDD-028: A potent, neuroprotective, non-opioid compound for the treatment of diabetic neuropathy
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Laura Micheli, Jagan Rajamoni, Lorenzo Di Cesare Mannelli, Parthasarathi Rajagopalan, Carla Ghelardini, Raghavan Rajagopalan
Synthesis and anti-tumor activities in human leukemia-derived cells of polyenylpyrroles with a methyl group at the conjugated polyene terminus
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Tomoya Higashi, Chihiro Yoshida, Yoshifumi Hachiro, Chihiro Nakata, Azusa Takechi, Takuya Yagi, Kazuya Miyashita, Nobuo Kitada, Rika Obata, Takashi Hirano, Takahiko Hara, Shojiro A. Maki
Potent and selective carbonic anhydrase inhibition activities of pyrazolones bearing benzenesulfonamides
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Suleyman Akocak, Nebih Lolak, Simone Giovannuzzi, Claudiu T. Supuran
Enhanced tumor specific drug release by hypoxia sensitive dual-prodrugs based on 2-nitroimidazole
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Takashi Tsuji, Honoka Tsunematsu, Masaki Imanishi, Masaya Denda, Koichiro Tsuchiya, Akira Otaka
Discovery of a non-covalent ligand for Rpn-13, a therapeutic target for hematological cancers
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Cody A. Loy, Christine S. Muli, Eslam M.H. Ali, Dan Xie, Mostafa H. Ahmed, Carol Beth Post, Darci J. Trader
Brain-penetrant cyanoindane and cyanotetralin inhibitors of G2019S-LRRK2 kinase activity
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Albert W. Garofalo, Jacob Schwarz, Kerry Zobel, Claudia Beato, Silvia Bernardi, Federica Budassi, Laura Caberlotto, Peng Gao, Cristiana Griffante, Xinying Liu, Marco Migliore, Feifei Qiao, Fabio Maria Sabbatini, Anna Sava, Mingliang Zhang, Holly J. Carlisle
Synthesis of mizoribine prodrugs and their <em>in vivo</em> evaluation as immunosuppressive agents
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Ling-Jie Gao, Yuan Lin, Steven De Jonghe, Mark Waer, Piet Herdewijn
Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Ahmed Fnaiche, Léa Mélin, Narjara González Suárez, Alexis Paquin, Victoria Vu, Fengling Li, Abdellah Allali-Hassani, Albina Bolotokova, Frédéric Allemand, Muriel Gelin, Philippe Cotelle, Simon Woo, Steven R. LaPlante, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Jean-François Guichou, Borhane Annabi, Alexandre Gagnon
Design, synthesis of auristatins-glucuronide conjugates targeting the β-glucuronidase in tumor microenvironment
Publication date: 15 October 2023
Source: Bioorganic & Medicinal Chemistry Letters, Volume 95
Author(s): Yujie Wang, Keshi Xu, Hongchun Liu, Wei Zhang, Chun Hu, Yingxia Li