Regioselective [2 + 1] photocycloaddition of 2-pyridones with diazo compounds

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01354E, Communication
Fengya He, Ziyi Sun, Chenyue Li, Zibin Jiang, Hui Miao, Qinglin Li, Chenggui Wu
A novel strategy for the regioselective cyclopropanation of 2-pyridones under photocatalyst-free conditions, showing excellent regio- and stereo-selectivity, is reported.
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Organic photoredox catalyzed C(sp3)–H functionalization of saturated aza-heterocycles via a cross-dehydrogenative coupling reaction

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01438J, Communication
Yi-Fan Zhang, Han-Nan Chen, Yi Xiao, Zhencun Cui, Wei David Wang, Guo-Qiang Xu
A novel organic photoredox catalyzed CDC reaction of aza-heterocycles with various groups including indole, naphthol, phenol, pyrrole, furyl, nitromethyl, and cyano, was established, providing a concise way to access α-functionalized cyclic amines.
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Fluorescent styryl pyridine-N-oxide probes for imaging lipid droplets

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01365K, Paper
Yogesh Dubey, Paramasivam Mahalingavelar, Deeksha Rajput, Dipeshwari J. Shewale, Virupakshi Soppina, Sriram Kanvah
Sub-cellular imaging with styryl fluorophores: the zwitterion labels lipid droplets and the cation stains mitochondria.
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Recent Advances in Metal Directed C─H Amidation/Amination using Sulfonyl Azides and Phosphroyl Azides

Org. Biomol. Chem., 2023, Accepted Manuscript
DOI: 10.1039/D3OB01160G, Review Article
Krishna Rao M V, Karim Shaik , Shaik Ramjan Vali , Venkata Subba Reddy Basireddy
Transition metal-catalyzed C−N bond formation reactions have gained popularity as a method for constructing N-functionalized molecules by selectively transforming ubiquitous C-H bonds. This approach is particularly useful for synthesizing aminated...
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Efficient, multi-hundred-gram scale access to E3 ubiquitin ligase ligands for degrader development

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB00983A, Paper
Mark S. Cooper, Mark C. Norley, Simon Armitage, Joel O. Cresser-Brown, Anthony K. Edmonds, Sean Goggins, Jonathan P. Hopewell, Burhan Karadogan, Kevin A. Knights, Toby J. Nash, Catherine S. Oakes, William J. O'Neill, Simon J. Pridmore, Hannah J. Maple, Graham P. Marsh
Supporting degrader discovery programs in scale and scope: facile access to multi-hundred-gram quantities of the common E3 ligase ligands.
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A fluorescent probe for selective detection of boric acids and its application for screening the conversion of the Suzuki–Miyaura coupling reaction

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01171B, Communication
Min Sik Eom, Byoung Yong Park, Seungyoon Kang, Min Su Han
A boric acid (B(OH)3) selective fluorescent probe, Di-OH, was developed, which was further applied for screening the conversion of the Suzuki–Miyaura coupling reaction.
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Borane catalyzed transesterification of tert-butyl esters using α-aryl α-diazoesters

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01548C, Communication
Maying Yan, Lei Xiao, Jiangkun Xiong, Lvnan Jin, Douglas W. Stephan, Jing Guo
B(C6F5)3 catalyzed transesterification of unsaturated tert-butyl esters with α-aryl α-diazo esters occurs in good yields (up to 99%) under mild reaction conditions, leaving the CC bonds intact.
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N-Hydroxy-Phe-Phe, a new dipeptide, and cytotoxic macrocyclic trichothecenes from the lethal toxic mushroom Podostroma cornu-damae

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01387A, Paper
Bum Soo Lee, Su Myung Jung, Rhim Ryoo, Sang Un Choi, Seongpil An, Ki Hyun Kim
A new dipeptide, N-hydroxy-Phe-Phe (1), and three macrocyclic trichothecenes, namely satratoxin H (2), 12′-episatratoxin H (3), and roridin F (4), were isolated from a plate culture of the poisonous mushroom Podostroma cornu-damae.
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Strengthened cooperativity of DNA-based cyclic hydrogen-bonded rosettes by subtle functionalization

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01391J, Paper
Open Access Open Access
David Almacellas, Célia Fonseca Guerra, Jordi Poater
Cooperative effects cause extra stabilization of hydrogen-bonded supramolecular systems.
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Harnessing the power of a photoinitiated thiol–ene “click” reaction for the efficient synthesis of S-lipidated collagen model peptide amphiphiles

Org. Biomol. Chem., 2023, Advance Article
DOI: 10.1039/D3OB01469J, Paper
Clouie Justin Aguilar, Makhdoom Sarwar, Sujay Prabakar, Wenkai Zhang, Paul W. R. Harris, Margaret A. Brimble, Iman Kavianinia
Thiolation by 2-iminothiolane followed by photoinitiated thiol–ene "click" reaction enabled the formation of S-lipidated collagen peptide amphiphiles. This methodology holds significant potential for the generation of functional peptide amphiphiles.
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