Biodegradable covalent organic frameworks achieving tumor micro-environment responsive drug release and antitumor treatment

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Biomater. Sci., 2023, 11,6524-6536
DOI: 10.1039/D3BM01088K, Paper
Tong Li, Dianwei Wang, Zhaopei Guo, Lin Lin, Meng Meng, Cong Liu, Kai Hao, Xuan Pang, Huayu Tian, Xuesi Chen
A biodegradable COF was constructed to break in response to tumors, enhancing the therapeutic effect on tumors.
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Chain-extension in hyperbranched polymers alters tissue distribution and cytotoxicity profiles in orthotopic models of triple negative breast cancers

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Biomater. Sci., 2023, 11,6545-6560
DOI: 10.1039/D3BM00609C, Paper
Open Access Open Access
Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Cara Moloney, Fatemeh Mehradnia, Robert J. Cavanagh, Asmaa Ibrahim, Amanda K. Pearce, Alison A. Ritchie, Philip Clarke, Ruman Rahman, Anna M. Grabowska, Cameron Alexander
The therapeutic efficacy of nanomedicines is highly dependent on their access to target sites in the body, and this in turn is markedly affected by their size, shape and transport properties in tissue.
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Dual-responsive PEG–lipid polyester nanoparticles for siRNA and vaccine delivery elicit anti-cancer immune responses by modulating tumor microenvironment

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Biomater. Sci., 2023, 11,6619-6634
DOI: 10.1039/D3BM01265D, Paper
Zixu Liu, Linxuan Zhao, Yupeng Feng, Qingqing Wang, Nan Dong, Yu Zhang, Tian Yin, Haibing He, Xing Tang, Jingxin Gou, Li Yang
Dual-responsive PEG-lipid polyester nanoparticles (PEG BR647-NPs) were employed as a vaccine and STAT3 siRNA carrier for tumor-targeted delivery to modulate the tumor microenvironment.
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Harnessing graphene oxide nanocarriers for siRNA delivery in a 3D spheroid model of lung cancer

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Biomater. Sci., 2023, 11,6635-6649
DOI: 10.1039/D3BM00732D, Paper
Open Access Open Access
Francesca Grilli, Eman M. Hassan, Fabio Variola, Shan Zou
Graphene oxide has been used as an effective nanocarrier for gene delivery in cancer cells in vitro.
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Fabrication and in vitro investigation of hyperbranched poly-lysine-grafted warp knitted polypropylene sling for potential treatment of stress urinary incontinence

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Biomater. Sci., 2023, 11,6504-6523
DOI: 10.1039/D3BM00943B, Paper
Shuying Zhao, Meiqi Fang, Yan Li, Fujun Wang, Hao Li, Lu Wang
Hyperbranched polylysine grafted polypropylene warp-knitted sling with mechanical compliance to prevent postoperative erosion.
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Efficient fabrication of thermo-stable dissolving microneedle arrays for intradermal delivery of influenza whole inactivated virus vaccine

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Biomater. Sci., 2023, 11,6790-6800
DOI: 10.1039/D3BM00377A, Paper
Jihui Lee, Martin Beukema, Oliwia A. Zaplatynska, Conor O'Mahony, Wouter L. J. Hinrichs, Anke L. W. Huckriede, Joke A. Bouwstra, Koen van der Maaden
WIV incorporated dMNAs produced by the dispensing method reduced antigen waste by 95% compared to the centrifugation method. They also maintained the stability of WIV and elicited similar immune responses to intramuscularly (I.M.) delivered WIV.
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Synthesis, characterization, and biological verification of asialoglycoprotein receptor-targeted lipopolysaccharide-encapsulated PLGA nanoparticles for the establishment of a liver fibrosis animal model

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Biomater. Sci., 2023, 11,6650-6662
DOI: 10.1039/D3BM01058A, Paper
Ching-Ju Huang, Shao-Jung Hsu, Yi-Chiung Hsu, Liang-Kun Chen, Chuan Li, Hui-Chun Huang, Yu-Hsiang Lee
ALPNPs with hepatocytic targetability can specifically induce hepatic fibrosis and exhibit significantly less toxicity in organs other than the liver in comparison to free LPS after 14-day treatment.
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Development of digital light processing-based multi-material bioprinting for fabrication of heterogeneous tissue constructs

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Biomater. Sci., 2023, 11,6663-6673
DOI: 10.1039/D3BM01054F, Paper
Hao Su, Bingxian Lu, Ming Li, Xue Yang, Minghao Qin, Yang Wu
A DLP-based multi-material bioprinting process was developed which mitigated bioink cross-contamination, damage to printed features, and waste of bioink. Constructs with multiple materials and complex structures could be readily obtained.
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