Acid-sensitive stable polymeric micelle-based oxidative stress nanoamplifier as immunostimulating anticancer nanomedicine

Biomater. Sci., 2023, 11,6600-6610
DOI: 10.1039/D3BM00770G, Paper
Gayoung Kwon, Jinsu Baek, Nuri Kim, Soonyoung Kwon, Nanhee Song, Seong-Cheol Park, Byeong-Su Kim, Dongwon Lee
Oxidative stress amplifying compounds that not only generate reactive oxygen species (ROS) but also deplete antioxidants could elicit selective killing of cancer cells with minimal toxicity to normal cells and also induce immunogenic cell death (ICD).
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Prodrug-loaded semiconducting polymer hydrogels for deep-tissue sono-immunotherapy of orthotopic glioblastoma

Biomater. Sci., 2023, 11,6823-6833
DOI: 10.1039/D3BM00585B, Paper
Liyun Zhu, Xing Wang, Mengbin Ding, Ningyue Yu, Yijing Zhang, Hongwei Wu, Qin Zhang, Jiansheng Liu, Jingchao Li
A novel sono-activatable prodrug hydrogel was developed to achieve deep-tissue sono-immunotherapy of orthotopic glioblastoma.
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Dendritic systems for bacterial outer membrane disruption as a method of overcoming bacterial multidrug resistance

Biomater. Sci., 2023, 11,6421-6435
DOI: 10.1039/D3BM01255G, Review Article
Kinga Skrzyniarz, Dorota Kuc-Ciepluch, Magdalena Lasak, Michał Arabski, Javier Sanchez-Nieves, Karol Ciepluch
Outer bacterial membrane disruption by dendritic systems as a way to overcome drug resistance.
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Graphene- and MXene-based materials for neuroscience: diagnostic and therapeutic applications

Biomater. Sci., 2023, 11,6687-6710
DOI: 10.1039/D3BM01114C, Review Article
Atefeh Zarepour, Çimen Karasu, Yousof Mir, Mohammad Hadi Nematollahi, Siavash Iravani, Ali Zarrabi
Therapeutic and diagnostic applications of graphene- and MXene-based materials in neuroscience are deliberated, focusing on important challenges and future prospects.
The content of this RSS Feed (c) The Royal Society of Chemistry

Prevention of esophageal stenosis via in situ cross-linkable alginate/gelatin powder in a new submucosal exfoliation model in rats

Biomater. Sci., 2023, 11,6781-6789
DOI: 10.1039/D3BM00887H, Paper
Qi Pan, Yosuke Tsuji, Athira Sreedevi Madhavikutty, Seiichi Ohta, Ayano Fujisawa, Natsuko F. Inagaki, Mitsuhiro Fujishiro, Taichi Ito
An in situ cross-linkable powder composed of alginate, gelatin, transglutaminase (TG), and calcium chloride ions (Ca2+) could prevent esophageal stenosis after endoscopic submucosal dissection (ESD) using novel rat ESD model.
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Synthetic lipo-polylysine with anti-cancer activity

Biomater. Sci., 2023, 11,6611-6618
DOI: 10.1039/D3BM01099F, Paper
Xuan Yi, Pengqi Wan, Wei Shen, Xiaonong Zhang, Peng Zhang, Chunsheng Xiao
A cationic lipo-polylysine C12-PLL13 can interact with negatively charged tumor cell membrane and induce cell necrosis by triggering membrane perforation and disintegration, offering a distinct therapeutic mechanism from traditional antitumor drugs.
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MMP-responsive nanomaterials

Biomater. Sci., 2023, 11,6457-6479
DOI: 10.1039/D3BM00840A, Review Article
Jiye Son, Sadiyah Parveen, Douglas MacPherson, Yaron Marciano, Richard H. Huang, Rein V. Ulijn
MMP-responsive nanomaterials can be used to control and amplify the spatial and temporal effects of anti-cancer treatments. This review focuses on the design strategies that can regulate and optimize enzyme specificity, access, and response.
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Sericin nano-gel agglomerates mimicking the pericellular matrix induce the condensation of mesenchymal stem cells and trigger cartilage micro-tissue formation without exogenous stimulation of growth factors in vitro

Biomater. Sci., 2023, 11,6480-6491
DOI: 10.1039/D3BM00501A, Paper
Qing Zhang, Wei Zhou, Futing Yang, Jifeng Shi
Soft agglomerates composed of sericin nano-gels induced MSCs to assemble into aggregations and direct them to differentiate into chondrocytes without extra stimulation.
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An anti-inflammatory chondroitin sulfate-poly(lactic-co-glycolic acid) composite electrospinning membrane for postoperative abdominal adhesion prevention

Biomater. Sci., 2023, 11,6573-6586
DOI: 10.1039/D3BM00786C, Paper
Rui Gao, Fenghui Li, Yushan Zhang, Pengxu Kong, Yu Gao, Jingrong Wang, Xiang Liu, Shuangyang Li, Liqin Jiang, Ju Zhang, Chuangnian Zhang, Zujian Feng, Pingsheng Huang, Weiwei Wang
A promising drug-/cytokine-free anti-inflammatory PLGA/CS electrospinning membrane barrier was developed for post-surgery abdominal adhesion prevention by alleviating the local inflammatory response and activating the fibrinolytic system.
The content of this RSS Feed (c) The Royal Society of Chemistry