The interactions of Cu (II) complexes with Schiff bases as ligands and DNA (ct-DNA/Salmon Sperm DNA) were investigated using electronic absorption, spectroscopic fluorescence method, and viscosity measurements and investigated by electrophoretic mobility shift assay. Cytotoxicity analyses were performed on human colorectal carcinoma HCT-166 and healthy lung fibroblast MRC-5.

Cancer remains one of the most common diseases worldwide in terms of deaths and claims many lives every day. Transition metal complexes are candidates in the development of anticancer drugs, with cisplatin being used in chemotherapy worldwide. Copper, an endogenous metal, is known for its pronounced redox potential and nucleophilicity, especially when bound to biological molecules. Cu (II) complexes were synthesized containing ethane-1,2-diamine as amine moiety and pentane-2,4-dione and/or 1-phenylbutane-1,3-dione, pentane-2,4-dione and/or 1,1,1-trifluoropentane-2,4-dione or 1,1,1-trifluoropentane-2,4-dione and/or 1-phenylbutane-1,3-dione as β-diketone moiety. Standard methods were used to confirm the structure of complexes 1–6. X-ray crystal structure analysis characterized complex 1 containing the ligand ethane-1,2-diamine and pentane-2,4-dione. The interactions of complexes 1–6 with calf thymus DNA (ct-DNA) were followed by electronic absorption and fluorescence spectroscopy methods and by viscosity measurements. In contrast, interaction with Salmon Sperm DNA was investigated using the electrophoretic mobility shift assay. The results indicate a moderate affinity of complexes 1–6 for binding to DNA. Gel electrophoresis also shows that the studied complexes have a concentration-dependent interaction with DNA. Spectroscopic fluorescence techniques were used to monitor the affinity of the complexes for bovine serum albumin (BSA). Complexes 1–6 showed satisfactory binding ability for BSA. Cytotoxicity analyses were performed on the human colorectal carcinoma HCT-116 and healthy lung fibroblast MRC-5 cell lines, showing that complex 5 exhibited selectivity between cancer and normal cells, which is critical for drug development.

Preparation of metal complexes of Girard-T hydrazones Geometry optimization, thermal degradation, and biological Studies of investigated compounds 3D molecular docking interaction of GT.O ligand towards the inhibitor to MCF-7 through a π–π stacking between aromatic ring and PHE856

This article details the synthesis of new Girard-T reagent ligands. Condensation of 2-hydroxyacetophenone or 2-acetyl-thiophene with Girard-T reagent results in new hydrazone ligands. The interaction of these Girard-T hydrazones with transition metal chlorides, like Au (III), Ru (III), Pd (II), and Pt (II), produces different complexes. Elements and spectrum analyses (IR, UV–Vis, EI-mass, and ¹H NMR) were used to characterize the isolated solid complexes, as well as conductimetric and magneto-chemical studies. Metal complexes can have different geometrical configurations, including square planar and octahedral coordination. The DMOL³ method, which is a part of the Material Studio package, was also utilized for structure optimization. Horowitz–Metzger and Coats–Redfern methods were utilized to calculate the various thermodynamic and kinetic parameters. The ligands and the complexes of their metal were evaluated for anticancer activity against carcinoma cervix (Prostate) and the mammary gland female breast (MCF-7) cell line having cancer, with promising results. Among these compounds, the Ru (III) and Pt (II) complexes' anticancer activity against (MCF-7) cell lines, comparable with that of 5-fluorouracil were carried out and their interactions were performed by molecular docking simulations against MCF-7 (PDB ID: 3W2S) receptor.

This study shows that the particle size of ZIF-67 can be controlled by adjusting the reactant concentration, enabling manipulation of the electrochemical properties as a sulfur host.

To improve the electrochemical performance of Li-S batteries, sulfur composites are prepared through sulfur's melt-diffusion into porous materials such as metal organic frameworks (MOFs). MOFs are porous nanocrystalline materials consisting of metal ions and organic ligands. Due to their high porosity, specific surface area, and easily controllable porous structure, MOFs and their derivatives are considered useful materials for holding sulfur. Herein, the effect of the concentration of the reactants on the particle diameter distribution of ZIF-67 is studied, and the performance of the product as a sulfur host for Li-S battery cathode is evaluated. ZIF-67 was prepared by regulating the Co²⁺ concentration in solution from 10 to 250 mM, with a constant mole ratio between Co²⁺ and the organic ligand. Cyclovoltammetry, galvanostatic charge–discharge, and rate capability tests were performed to electrochemically characterize each sample as a sulfur host for Li-S battery cathodes. MeZ-50 mM, prepared with 50 mM Co²⁺ ion solution, had the smallest particle diameter (591 nm). The sulfur cathode utilizing MeZ-50 mM afforded the best electrochemical performance (883.7 mAh g_S ⁻¹). This study demonstrates that the particle size of ZIF-67 can be controlled by adjusting the reactant concentration, enabling manipulation of the electrochemical properties as a sulfur host.