Construction of Crystalline Porous Frameworks (COF/MOF) with Multi‐components or by Multi‐reactions

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Construction of Crystalline Porous Frameworks (COF/MOF) with Multi-components or by Multi-reactions

MOFs and COFs have developed their own construction principles and methodologies. The process of learning and adopting each other's methodologies in structural design and synthesis is an emergent hot area and will be further developed. This view highlights the recent emerging development of a multi-component/reaction strategy for covalent organic framework (COF) synthesis and its application in new MOF synthetic strategy and ligand development.


Abstract

Covalent organic frameworks (COFs) and metal organic frameworks (MOFs) are crystalline porous materials with ordered framework structures. To create diverse framework structures, linkers with different geometries and sizes have been developed over the past decades. However, for more advanced applications, there is a need for continuous pore size control and property development. Researchers are exploring new synthesis methods, building blocks, and processing/fabrication protocols to meet these demands. Multi-component or multiple ligands synthesis has been widely used in the construction of MOF structures, and this synthetic strategy has recently been adopted for COF synthesis and extended to versatile linker designing strategies. This review focuses on the recent development of the multi-component or multi-reaction strategy for COF synthesis, its application in new MOF synthetic strategies, and ligand development.

ESIPT‐Active Pyrene‐imidazole Fluorophores: GSIPT, Dual Solid‐ and Solution‐State Emission plus Counter‐Intuitive Crystal Packing

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ESIPT-Active Pyrene-imidazole Fluorophores: GSIPT, Dual Solid- and Solution-State Emission plus Counter-Intuitive Crystal Packing**

A novel pyrene-imidazole-based ESIPT-active molecules have been developed that exhibit unique ground state enol to keto transformation and dual solid- and solution-state emission.


Abstract

We report a new excited-state intramolecular proton transfer (ESIPT)-inspired hydroxyl (OH)-substituted pyrene-imidazole that promote unprecedented intramolecular proton transfer in the ground state (GSIPT). The enol and keto isomers are in equilibrium, with a high keto-isomer component in the solid state. In conjunction with DFT calculations, the photophysical studies and crystal structure analysis shred substantial evidence for the ground state transformation. The ESIPT-active compounds also show the rare feature of high dual solution (φf=70 %) and solid state (φf=41 %) emission characteristics and counter-intuitive stronger intermolecular interactions in the solid state versus the ESIPT-inactive counterparts.

Advances in Mass Spectrometry‐Based Structural Proteomics: Development of HDX‐MS and XL‐MS Techniques from Recombinant Protein to Cellular Systems

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Advances in Mass Spectrometry-Based Structural Proteomics: Development of HDX-MS and XL-MS Techniques from Recombinant Protein to Cellular Systems


Abstract

Mass spectrometry (MS) is a central analytical technique used to study proteins and biomolecules. It measures mass-to-charge ratio of ions to identify and quantify molecules in simple and complex mixtures. Technological advancement in instrumentation, sample preparation methodologies, and data analysis workflows continue to push the capabilities of MS to answer more complicated questions and vice versa. Structural proteomics uses MS-based methodologies to characterize protein structure. Specifically, but not limited to, hydrogen deuterium exchange MS (HDX-MS) and crosslinking MS (XL-MS) are complementary techniques that capture the structural plasticity inherent to proteins in solution. This review is intended to present recent progress in HDX-MS and XL-MS that have allowed these techniques to be used not only for simple recombinant protein systems but with complex cellular systems.