Parameter Identification of a Solid Oxide Fuel Cell Model under Different Temperature Conditions

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Parameter Identification of a Solid Oxide Fuel Cell Model under Different Temperature Conditions

A nature-inspired evolutionary algorithm, black widow optimization (BWO), for parameter identification is proposed and applied to a 5-kW tubular solid oxide fuel cell system. A series of test runs on minimization of standard benchmark functions have been performed and compared with other metaheuristic algorithms. In terms of accuracy, robustness, convergence, and statistics, BWO is a competitive method.


Abstract

A new effective method for optimization of unknown parameters in solid oxide fuel cell (SOFC) stack models is suggested. The overall voltage of the SOFC stack depends on these predicted parameters. The goal is to reduce the mean square error (MSE) between the empirical and the predicted polarization curve obtained using the method. Black widow optimization (BWO), a metaheuristic method inspired by nature, describes the minimization process. This algorithm is made to alter the search space, avoid local optima, and deliver greater efficiency in the exploitation and exploration stages. Situations based on multidimensional benchmark functions and SOFC stack temperature variations are investigated to ascertain the system consistency.

Could Drug Availability Be Improved through Shape Modification?

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Could Drug Availability Be Improved through Shape Modification?

Spherical agglomeration has the potential to improve the handling of unfavourably shaped crystals. A large number of process parameters must be adjusted to carry out spherical agglomeration, which is a challenging task, especially for complex organic molecules. The possibility of preparing spherical crystals in different solvent systems for two active pharmaceutical ingredients is examined.


Abstract

The possibility of spherical agglomeration was investigated for two active pharmaceutical ingredients from different classes of the Biopharmaceutics Classification System. The effects of different batch crystallization solvent systems on the granulometric properties and structures of dronedarone hydrochloride and ceritinib were investigated. Light and stereomicroscopy were used to determine the size and shape of the agglomerates, while X-ray powder diffraction was applied to assess the changes in polymorphic form. Since the change in the solvent system had no effect on the crystal structure but did alter the size and shape of the crystals, dissolution experiments were carried out to determine drug release profiles.

Peptide and Peptidomimetic Assemblies in Dynamic Combinatorial Chemistry

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Peptide and Peptidomimetic Assemblies in Dynamic Combinatorial Chemistry

Dynamic combinatorial library of peptides can be generated either through amino-acid like monomers oligomerization, amino-acid side-chain grafting on static scaffolds or pre-synthesized peptide assembly. These stimuli responsive libraries are of great value for screening purpose in drug discovery, biosensing or material sciences.


Abstract

A strong revival of interest has been dedicated to peptides over the last few years, in different fields including drug discovery, biosensing and material sciences. The use of dynamic covalent chemistry has allowed the development of self-adaptative peptides or peptidomimetics, responsive to their environment. The development of methods allowing the building, screening or deconvolution of libraries of peptides is a highly active research area and dynamic combinatorial chemistry represents an innovative and underexploited method in this field. This Review gives an overview of the use of dynamic covalent chemistry as a tool to produce peptides or peptidomimetics, with particular attention to applications in dynamic combinatorial chemistry.

Effect of Cucurbit[7]uril on contrasting binding with flavonoids: Insights from spectroscopy and calorimetric studies

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Effect of Cucurbit[7]uril on contrasting binding with flavonoids: Insights from spectroscopy and calorimetric studies

We observed all the three flavonoids used in this work form 1:2 complex with CB[7]. Isothermal titration calorimetry study indicates that the complex formation process at room temperature is endothermic in nature. From our result, we observed a comparative binding feature form fluorescence and isothermal titration calorimetry measurement.


Abstract

Due to intrinsic fluorescence behavior, and the environment-dependent excited-state intramolecular proton transfer (ESIPT) process, makes special attention towards flavonoids for conducting photophysical study. The binding of fisetin, morin hydrate, and quercetin with macrocyclic molecule Cucurbit[7]urils (CB[7]) has been studied using different spectroscopic methods. The changes in the thermodynamic parameters during complex formation between the flavonoids with CB[7] are estimated by an isothermal titration calorimetry study. From the spectroscopic measurement, we have seen that in the presence of CB[7], flavonoids show the ESIPT process and the prototropic equilibrium is present between different forms of flavonoids. The isothermal titration calorimetry study shows that the complex formation between these flavonoids with CB[7] spontaneously takes place at room temperature, which is an endothermic process.