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Statement of Retraction: A Co(II)-mediated coordination polymer: treatment capability on post-traumatic osteoarthritis via reducing inflammatory response
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Statement of Retraction: A new Co(II)-based coordination polymer: crystal structure and treatment activity on Alzheimer’s disease by reducing the accumulation of Aβ
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Calculation of the T – X phase diagram and the thermodynamic quantities for the binary mixtures of Tetradecane + Hexadecane using the Landau mean field model
Selective and sensitive colorimetric detection of Cr(VI) using porous M3V2O8 (M= Ni, Cu, and Zn) nanostructures as oxidase mimics
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Assessment of annual effective dose from radionuclides in paint materials using High Purity Germanium detector
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The antioxidant properties of Spirulina (microalgae) can reduce oxidative stress and neurotoxicity caused by mercury in freshwater mussels
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A Tribute to Richard Lerner (1938–2021) who Encouraged a Glycobiology Approach to a Broad‐Spectrum Antiviral
Abstract
Richard Lerner was a visionary polymath of the 20th century; a medical doctor, chemist, immunologist, inventor, and founder of new scientific fields. As a tribute to his life and scientific achievements, we discuss his connection with Oxford University and the Glycobiology Institute and we discuss our research data on the host glycoprotein folding pathway and how its inhibition can lead to broad spectrum antiviral drugs. This host targeting approach for developing antiviral therapies has the advantage of being effective against many viruses, therefore can be used to prevent new epidemics to become pandemics.
Calix[5]arene Self‐Folding Cavitands: a New Family of Bio‐Inspired Receptors with Enhanced Induced Fit Behavior
![Calix[5]arene Self-Folding Cavitands: a New Family of Bio-Inspired Receptors with Enhanced Induced Fit Behavior](https://onlinelibrary.wiley.com/cms/asset/a3bd80bb-ab0f-4b68-9803-cda526cf5f91/ijch202300077-toc-0001-m.png)
Abstract
Self-folding cavitands represent the quintessential form of bioinspired synthetic receptors, featuring deep hydrophobic cavities that engage in host-guest chemistry reminiscent of that operating in biomolecules. Although remarkable proof-of-concept applications have been reported, the narrow and rigid spaces of the legacy resorcin[4]arene derived hosts constitute a liability towards the development of specific applications in catalysis, sensing or sequestration. While notable efforts to expand the size of the cavities have been reported, the development of confined spaces reproducing the highly adaptable nature of biological receptors is a largely unaddressed issue. This review summarizes the development of a new family of calix[5]arene derived self-folding cavitands displaying enhanced induced fit and conformational selection phenomena. Our approach capitalizes on hydrogen bonding preorganization rather than the covalent restriction approaches customary of conventional supramolecular chemistry.
Substituent influence of heteroatom on the novel remote N-heterocyclic silylenes (RNHSis) using density functional theory
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