Nature Immunology, Published online: 12 April 2024; doi:10.1038/s41590-024-01817-w

Here, the authors describe biallelic loss-of-function variants in human SHARPIN in individuals with autoinflammation and immunodeficiency, termed sharpenia. They also successfully treat one of these individuals with TNF inhibitors.

Nature Immunology, Published online: 12 April 2024; doi:10.1038/s41590-024-01814-z

In this Resource, the authors integrate multiomics data to show the effect of the transcription factors Blimp-1 and c-Maf on IL-10 and type 1 and 17 responses, which together protect against pathobiont-induced colitis.

Nature Immunology, Published online: 10 April 2024; doi:10.1038/s41590-024-01808-x

Cupedo and colleagues show that neutrophils promote a tumor-supportive microenvironment via a self-amplifying interaction between neutrophils and bone marrow stromal cells. This scenario creates a promyeloma niche that is difficult to treat despite targeted therapies directed at the myeloma cells.

Nature Immunology, Published online: 10 April 2024; doi:10.1038/s41590-024-01810-3

Inflammatory memory cues initiated by neutrophils and bone marrow stroma suggest potential therapeutic targets for the treatment of multiple myeloma.

Nature Immunology, Published online: 10 April 2024; doi:10.1038/s41590-024-01827-8

Author Correction: Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

Nature Immunology, Published online: 08 April 2024; doi:10.1038/s41590-024-01803-2

Kratchmarov et al. identified a GATA3+ TH2 population that expresses the transcription factors TCF1 and LEF1 and sustains type 2 inflammation in tissues over a human lifetime, despite chronic antigen exposure.

Nature Immunology, Published online: 08 April 2024; doi:10.1038/s41590-024-01811-2

Here the authors identify the transcription factor MEF2C as essential for human NK cell function and viral immunity in mice and humans. This control is exerted via regulation of lipid metabolism, and deficiency in MEF2C can be overcome by oleic acid supplementation.

Nature Immunology, Published online: 08 April 2024; doi:10.1038/s41590-024-01795-z

Profiling of plasma proteins in individuals with COVID-19 shows that complement activation and myeloid inflammation are major pathways in the pathogenesis of long COVID and identifies distinct profiles of immune dysregulation in individuals with long COVID, highlighting the heterogeneous and diverse nature of this disease.

Nature Immunology, Published online: 09 October 2023; doi:10.1038/s41590-023-01636-5

The malate shuttle is understood to control the NAD+/NADH balance. Here the authors show that GOT1, a central enzyme in the malate shuttle, rather promotes antiviral CD8+ T cell responses by detoxifying ammonia.

Nature Immunology, Published online: 09 October 2023; doi:10.1038/s41590-023-01634-7

Yuan and colleagues show that ERMAP expression on cancer cells delivers an ‘eat me’ signal to Kupffer cells by binding to Gal-9–dectin-2 on Kupffer cells and triggering phagocytosis.