Nature Immunology, Published online: 09 October 2023; doi:10.1038/s41590-023-01647-2

Kupffer cells, hepatic resident macrophages, are the first line of defense against liver metastases by engulfing disseminated malignant cells. We found that ERMAP expressed on tumor cells binds to galectin-9 and dectin-2 on Kupffer cells to deliver pro-phagocytosis ‘eat me’ signals to Kupffer cells to restrict liver metastases.

Nature Immunology, Published online: 09 October 2023; doi:10.1038/s41590-023-01650-7

For decades, beta-blockers have been used widely to treat cardiovascular diseases. Surprisingly, new data show how these inhibitors can also improve immunotherapy against tumors and chronic infections.

Nature Immunology, Published online: 05 October 2023; doi:10.1038/s41590-023-01642-7

Peduto and colleagues report a role for ADAM12+ mesenchymal stromal cells at the tumor margins and their interaction with immune cells to promote a permissive ‘protumor’ environment.

Nature Immunology, Published online: 02 October 2023; doi:10.1038/s41590-023-01625-8

Current acellular pertussis vaccines prevent disease but do not prevent nasal infection and transmission of Bordetella pertussis. However, immunology is helping to design new vaccines that induce sterilizing immunity.

Nature Immunology, Published online: 28 September 2023; doi:10.1038/s41590-023-01630-x

The first conference on ‘Infection and Immunity’ was organized by the Institute for Basic Science and Korean Association of Immunologists and held in Daejeon, South Korea, from 12 to 14 July 2023. The conference focused on the biology of CD8+ T cells in the context of viral disease and cancer.

Nature Immunology, Published online: 25 September 2023; doi:10.1038/s41590-023-01606-x

On 20–23 June 2023, the 10th International γδ T cell conference was held in Lisbon, Portugal, bringing together basic, translational and clinical researchers studying γδ T cells in health and disease.